Previous work between Bangor and Sophimark has shown that a charged dye placed between electrodes within a solid matrix can be controlled by the application of electric fields. As part of the CALIN program, continued work with Sophimark will allow rigorous evaluation to be conducted in order to show that a fully integrated device can be developed. Partners: Sophimark Ltd, Bangor University & University College Cork
The project originated from initial work conducted in 2012 between Bangor and Sophimark on the manipulation of molecules within solid matrix material by the application of electrical fields. The first data sets conducted at Bangor showed that a charged dye placed between electrodes within a solid matrix could be controlled within a specific area of the matrix by the application of electric fields. Follow on experiments with components of an isothermal nucleic acid amplification reaction showed that an amplification reaction could be conducted within a solid matrix. These initial experiments illustrated the basic proof of principle. However, a rigorous evaluation needs to be conducted in order to show that a fully integrated device can be developed, where sample preparation, nucleic acid amplification and detection, can all be performed within a single solid matrix-based device.
Partners: Sophimark Ltd, Bangor University & University College Cork